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- Hypersensitivity to the drug or any of the inactive ingredients
- Patients below 18 and above 65 years of age
- History of peripheral arterial disease
- Hypertension that is not sufficiently controlled (e.g., >145/90 mmHg), caution in controlled hypertension
- Existing pulmonary hypertension
- Existing damage on heart valves, coronary heart disease, congestive heart failure, serious arrhythmias, previous myocardial infarction
- A history of coronary artery disease (e.g., angina, history of myocardial infarction), congestive heart failure, tachycardia, peripheral arterial
- occlusive disease, arrhythmia or cerebrovascular disease (stroke or transient ischemic attack (TIA))
- Stroke or transient ischemic attack (TIA)
- Hyperthyroidism (overactive thyroid gland)
- Closed-angle glaucoma
- Seizure disorders
- Enlargement of the prostate gland with urinary retention (relative contraindication)
- Pregnant and lactating women (relative contraindication). online.
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